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Curriculum Vitae

Hend Kather Abdelhakem Elhamalawy

Faculty pharmacy - Department Medicinal Chemistry Department
NULL

Scientific degrees

BSc In NULL, [2006]
MSc In NULL, [2010]
(And the construction of a biological survey of derivative Kinasulan 4 (3 hands) and new online Bnzotrazibn)
PhD In NULL, [2014]

الحالة الوظيفية الحالية :

قائم بالعمل

Academic Jobs

معيد : 2/10/2006
Doctor Assisant : 28/4/2010
Doctor : 25/2/2014
Professor Assisant : 28/5/2019
Professor : 27/8/2024

Publications

1 - Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides (2013).

2 - Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation (2010).

3 - Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity (2013).

4 - Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization (2013).

5 - Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors (2016).

6 - Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization (2016).

7 - Preclinical evaluation of Rad6 inhibition to overcome platinum resistance in ovarian cancer (2016).

8 - RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance (2017).

9 - Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives (2017).

10 - Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives (2017).

11 - Design, synthesis and biological evaluation of novel quinazoline-2,4- diones conjugated with different amino acids as potential chitin synthase inhibitors (2018).

12 - Synthesis, In vivo and In silico Evaluation of Novel 2,3-Dihydroquinazolin-4(1H)-one Derivatives as Potential Anticonvulsant Agents (2019).

13 - 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inﬂammatory and analgesic agents with an improved gastric proﬁle: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study (2018).

14 - Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inﬂammatory response via dual COX-2 and 15-LOX inhibition (2021).

15 - Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities (2021).

16 - Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities (2021).

17 - Quinazoline‐tethered hydrazone: A versatile scaffold toward dual anti‐TB and EGFR inhibition activities in NSCLC (2021).

18 - Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues (2021).

19 - Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation (2022).

20 - Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation (2023).

21 - Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity (2023).

22 - Design, Synthesis and Evaluation of Novel Inhibitors of E2 Ubiquitin Conjugating Enzyme as Potential Breast Cancer Therapeutics (2024).

23 - Synthesis and biological screening of new quinazolin-4(3H)-one and benzotriazepine derivatives (2024).

24 - Synthesis of New 2,3-dihydroquinazolinones and their Tricyclic Derivatives for Biological Evaluation (2024).

25 - Synthesis of 1, 2, 4‐triazole and 1, 3, 4‐oxadiazole derivatives as inhibitors for STAT3 enzymes of breast cancer (2023).

26 - Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines (2023).

27 - Design and Synthesis of Novel Thienopyrimidine Derivatives with Potential Biological Activity (2024).

28 - Novel 2-[thio]acetamide linked quinazoline/1,2,4-triazole/chalcone hybrids: Design, synthesis, and anticancer activity as EGFR inhibitors and apoptotic inducers (2024).

29 - Vitamin D3 mitigates myopathy and metabolic dysfunction in rats with metabolic syndrome: the potential role of dipeptidyl peptidase‑4 (2024).

Research Area

الكيمياء الطبية