بحث بيانات أعضاء هيئة التدريس - جامعة الزقازيق

/ بحث بيانات أعضاء هيئة التدريس - جامعة الزقازيق

هند كثير عبد الحكيم الحملاوى

الموقع الشخصى
السيرة الذاتية

هند كثير عبد الحكيم الحملاوى

الكلية الصيدلة - القسم الكيمياء الدوائية
الكيمياء الطبيه

الدرجات العلمية

بكالوريوس فى الكيمياء الطبيه, -جامعة الزقازيق [2006]
ماجستير فى الكيمياء الطبيه, -جامعة الزقازيق [2010]
(تشييد ومسح بيولوجى لمشتقات كينازولين 4 (3 يد) اون وبنزوترازيبن الجديدة)
دكتوراه فى الكيمياء الطبيه, -جامعة الزقازيق [2014]
(تصميم مثبطات الإنزيم المساعد على ارتباط البيكو تنيت إي 2 وتقييمها لعلاج سرطان الغدد)

الحالة الوظيفية الحالية :

قائم بالعمل

التدرج الوظيفى الأكاديمى

معيد : 2/10/2006
مدرس مساعد : 28/4/2010
مدرس : 25/2/2014
أستاذ مساعد : 28/5/2019
أستاذ : 27/8/2024

الأبحاث العلمية

1 - Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides (1435).

2 - Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation (1431).

3 - Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity (1434).

4 - Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization (1434).

5 - Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors (1437).

6 - Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization (1437).

7 - Preclinical evaluation of Rad6 inhibition to overcome platinum resistance in ovarian cancer (1437).

8 - RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance (1438).

9 - Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives (1438).

10 - Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives (1438).

11 - Design, synthesis and biological evaluation of novel quinazoline-2,4- diones conjugated with different amino acids as potential chitin synthase inhibitors (1439).

12 - Synthesis, In vivo and In silico Evaluation of Novel 2,3-Dihydroquinazolin-4(1H)-one Derivatives as Potential Anticonvulsant Agents (1440).

13 - 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inﬂammatory and analgesic agents with an improved gastric proﬁle: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study (1440).

14 - Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inﬂammatory response via dual COX-2 and 15-LOX inhibition (1442).

15 - Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities (1442).

16 - Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities (1443).

17 - Quinazoline‐tethered hydrazone: A versatile scaffold toward dual anti‐TB and EGFR inhibition activities in NSCLC (1443).

18 - Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues (1443).

19 - Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation (1443).

20 - Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation (1444).

21 - Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity (1445).

22 - Design, Synthesis and Evaluation of Novel Inhibitors of E2 Ubiquitin Conjugating Enzyme as Potential Breast Cancer Therapeutics (1445).

23 - Synthesis and biological screening of new quinazolin-4(3H)-one and benzotriazepine derivatives (1445).

24 - Synthesis of New 2,3-dihydroquinazolinones and their Tricyclic Derivatives for Biological Evaluation (1445).

25 - Synthesis of 1, 2, 4‐triazole and 1, 3, 4‐oxadiazole derivatives as inhibitors for STAT3 enzymes of breast cancer (1445).

26 - Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines (1444).

27 - Design and Synthesis of Novel Thienopyrimidine Derivatives with Potential Biological Activity (1445).

28 - Novel 2-[thio]acetamide linked quinazoline/1,2,4-triazole/chalcone hybrids: Design, synthesis, and anticancer activity as EGFR inhibitors and apoptotic inducers (1446).

29 - Vitamin D3 mitigates myopathy and metabolic dysfunction in rats with metabolic syndrome: the potential role of dipeptidyl peptidase‑4 (1446).

المجالات البحثية

الكيمياء الطبية