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Curriculum Vitae

Wael Mohamed Ali Ali Abdelhakiem

Faculty pharmacy - Department Microbiology and Immunology Department
NULL

Scientific degrees

BSc In NULL, [2001]
MSc In NULL, [2006]
PhD In NULL, [2011]

الحالة الوظيفية الحالية :

معار

Academic Jobs

معيد : 26/11/2001
Doctor Assisant : 23/4/2006
Doctor : 28/2/2012
Professor Assisant : 28/11/2017
Professor : 27/12/2022

Publications

1 - Studies on Pseudomonas Cepacia Isolated from Cystic Fibrosis Patients and Narural Sourses.

2 - Salmonella enterica as a vaccine carrier (2012).

3 - Potent therapeutic activity of a novel Salmonella-based cancer vaccine (2013).

4 - Evaluation of Salmonella enterica type III secretion system effector proteins as carriers for heterologous vaccine antigens (2012).

5 - Effective cancer vaccine platform based on attenuated salmonella and a type III secretion system (2014).

6 - Hepatitis C virus pathogenesis: Serum IL-33 level indicates liver damage (2015).

7 - Antibiotic resistance of Enterococcus faecalis and Enterococcus faecium isolated from urinary tract infections in Zagazig University hospitals (2016).

8 - Evaluation of the role of SsaV ‘Salmonella pathogenicity island-2 dependent type III secretion system components on the virulence behavior of Salmonella enterica serovar Typhimurium (2017).

9 - Targeting the virulence factors of Serratia marcescens by ambroxol (2017).

10 - Prevalence of multi-drug resistant Staphylococci isolated from surgical site infections (2018).

11 - Development of an Effective Cancer Vaccine Using Attenuated Salmonella and Type III Secretion System to Deliver Recombinant Tumor-Associated Antigens (2014).

12 - TALENs Construction: Slowly but Surely (2016).

13 - Diclofenac inhibits virulence of Proteus mirabilis isolated from diabetic foot ulcer (2016).

14 - Benzotriazole-Mediated Synthesis and Antibacterial Activity of Novel N-Acylcephalexins (2016).

15 - The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways (2017).

16 - Investigating the influence of iron on Campylobacter jejuni transcriptome in response to acid stress (2020).

17 - Ciprofloxacin interferes with Salmonella Typhimurium intracellular survival and host virulence through repression of Salmonella pathogenicity island-2 (SPI-2) genes expression (2020).

18 - Repurposing anti-diabetic drug “Sitagliptin” as a novel virulence attenuating agent in Serratia marcescens (2020).

19 - Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa (2020).

20 - Promising Antibiofilm Agents: Recent Breakthrough against Biofilm Producing Methicillin-Resistant Staphylococcus aureus (2020).

21 - Thymol Nanoemulsion: A New Therapeutic Option for Extensively Drug Resistant Foodborne Pathogens (2020).

22 - Pulmonary Targeting of Inhalable Moxifloxacin Microspheres for Effective Management of Tuberculosis (2021).

23 - Ciproloxacin interferes with Salmonella Typhimurium intracellular survival and host virulence through repression of Salmonella pathogenicity island-2 (SPI-2) genes expression (2020).

24 - Synthesis of Gold Nanoparticles by Using Green Machinery: Characterization and In Vitro Toxicity (2021).

25 - Pulmonary Targeting of Inhalable Moxifloxacin Microspheres for Effective Management of Tuberculosis (2021).

26 - Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma (2021).

27 - Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens (2021).

28 - Tackling Virulence of Pseudomonas aeruginosa by the Natural Furanone Sotolon (2021).

29 - Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System (2021).

30 - A novel use of allopurinol as a quorum sensing inhibitor in Pseudomonas aeruginosa (2021).

31 - Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System (2021).

32 - Retrospective Study of Bone-TB in Oman: 2002–2019 (2021).

33 - Anti-diabetics and antimicrobials: Harmony of mutual interplay (2021).

34 - Repurposing of antidiabetics as Serratia marcescens virulence inhibitors (2021).

35 - Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer (2021).

36 - Controlling of Bacterial Virulence: Evaluation of Anti-Virulence Activities of Prazosin against Salmonella enterica (2022).

37 - Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis (2022).

38 - Sodium Citrate Alleviates Virulence in Pseudomonas aeruginosa (2022).

39 - Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus (2022).

40 - Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins (2023).

41 - Biofilm Lifestyle in Recurrent Urinary Tract Infections (2023).

42 - Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors (2022).

43 - Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis (2022).

44 - Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo [3, 4–d] pyrimidines: Synthesis, antitumor evaluation and molecular modeling study (2022).

45 - Controlling of Bacterial Virulence: Evaluation of Anti-Virulence Activities of Prazosin against Salmonella enterica (2022).

46 - Characterization of the Anti-Biofilm and Anti-Quorum Sensing Activities of the β-Adrenoreceptor Antagonist Atenolol against Gram-Negative Bacterial Pathogens (2022).

47 - Silencing of Salmonella typhimurium Pathogenesis: Atenolol Acquires Efficient Anti-Virulence Activities (2022).

48 - Muting Bacterial Communication: Evaluation of Prazosin Anti-Quorum Sensing Activities against Gram-Negative Bacteria Pseudomonas aeruginosa, Proteus mirabilis, and Serratia marcescens (2022).

49 - Amphotericin B-PEG Conjugates of ZnO Nanoparticles: Enhancement Antifungal Activity with Minimal Toxicity (2022).

50 - Sodium Citrate Alleviates Virulence in Pseudomonas aeruginosa (2022).

51 - Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus (2022).

52 - Terazosin Interferes with Quorum Sensing and Type Three Secretion System and Diminishes the Bacterial Espionage to Mitigate the Salmonella Typhimurium Pathogenesis (2022).

53 - Novel In Vivo Assessment of Antimicrobial Efficacy of Ciprofloxacin Loaded Mesoporous Silica Nanoparticles against Salmonella typhimurium Infection (2022).

54 - Repurposing α-Adrenoreceptor Blockers as Promising Anti-Virulence Agents in Gram-Negative Bacteria (2022).

55 - Synthesis, Antimicrobial, Anti-Virulence and Anticancer Evaluation of New 5(4H)-Oxazolone-Based Sulfonamides (2022).

56 - Computational and Biological Evaluation of β-Adrenoreceptor Blockers as Promising Bacterial Anti-Virulence Agents (2022).

57 - Clonal Diversity and Epidemiological Characteristics of ST239-MRSA Strains (2022).

58 - Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients (2022).

59 - Characterization of the Anti-Biofilm and Anti-Quorum Sensing Activities of the β-Adrenoreceptor Antagonist Atenolol against Gram-Negative Bacterial Pathogens (2022).

60 - Silencing of Salmonella typhimurium Pathogenesis: Atenolol Acquires Efficient Anti-Virulence Activities (2022).

61 - Muting Bacterial Communication: Evaluation of Prazosin Anti-Quorum Sensing Activities against Gram-Negative Bacteria Pseudomonas aeruginosa, Proteus mirabilis, and Serratia marcescens (2022).

62 - Biofilm Lifestyle in Recurrent Urinary Tract Infections (2023).

63 - Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins (2023).

64 - The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens (2023).

65 - Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria (2023).

66 - Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate (2023).

67 - Synergistic Benefits: Exploring the Anti-Virulence Effects of Metformin/Vildagliptin Antidiabetic Combination against Pseudomonas aeruginosa via Controlling Quorum Sensing Systems (2023).

68 - Relocating Glyceryl Trinitrate as an Anti-Virulence Agent against Pseudomonas aeruginosa and Serratia marcescens: Insights from Molecular and In Vivo Investigations (2023).

69 - The anti-staphylococcal fusidic acid as an efflux pump inhibitor combined with fluconazole against vaginal candidiasis in mouse model (2024).

70 - Urinary Tract Infections - New Insights (2023).

71 - A Prospective Cohort Study of COVID-19: Evaluation of the Early Role of IL-1 and IL-6 Antagonists in Improving the Outcome of the Illness and Reduction in the Risk of Death (2023).

72 - What’s old is new again: Insights into diabetic foot microbiome (2024).

73 - Analytical Methodologies for the Estimation of Oxazolidinone Antibiotics as Key Members of anti-MRSA Arsenal: A Decade in Review (2023).

74 - Antimicrobial and anti-virulence activities of 4-shogaol from grains of paradise against gram-negative bacteria: Integration of experimental and computational methods (2024).

75 - Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria (2023).

76 - The anti-staphylococcal fusidic acid as an efflux pump inhibitor combined with fluconazole against vaginal candidiasis in mouse model (2024).

Research Area