بحث بيانات أعضاء هيئة التدريس - جامعة الزقازيق

/ بحث بيانات أعضاء هيئة التدريس - جامعة الزقازيق

لايوجد

الموقع الشخصى
السيرة الذاتية

كامل عبدالرحيم متولى بيومى

الكلية الصيدلة - القسم الكيمياء الدوائية
الكيمياء الطبيه

الدرجات العلمية

بكالوريوس فى الكيمياء الطبيه, -جامعة الزقازيق [1990]
ماجستير فى الكيمياء الطبيه, -جامعة الزقازيق [1995]
(لا يوجد)
دكتوراه فى الكيمياء الطبيه, -جامعة الزقازيق [1998]
(لا يوجد)

الحالة الوظيفية الحالية :

قائم باجازة خاصة

التدرج الوظيفى الأكاديمى

معيد : 22/9/1990
مدرس مساعد : 9/3/1995
مدرس : 24/11/1998
أستاذ مساعد : 12/9/2007
أستاذ : 27/3/2018

الأبحاث العلمية

1 - Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives (1437).

2 - Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives (1437).

3 - Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding (1418).

4 - Ketanserin and spiperone as templates for novel serotonin 5-HT2A antagonists (1422).

5 - Hydrazones of 2-arylquinoline-4-carboxylic acid hydrazides: synthesis and preliminary evaluation as antimicrobial agents (1427).

6 - Non-carboxylic analogues of aryl-propionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential (1428).

7 - Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: synthesis and in vitro cytotoxic activity (1428).

8 - Synthesis and biological activity of 2,5-diaryl-3-methyl-pyrimidino[4,5-c]quinolin-1(2H)-one derivatives (1428).

9 - . Synthesis, in-vitro Cytotoxicity, and a Preliminary Structure-Activity Relationship Investigation of Pyrimido[4,5-c]quinolin-1(2H)-ones (1431).

10 - Structure-activity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones (1434).

11 - The antimitotic pyrimido[4,5-c]quinolin-1(2H)-one scaffold: probing substituents at position 3 (1436).

12 - 1,3,4-Oxadiazole-2-thione derivatives; novel approach for anticancer and tubulin polymerization inhibitory activities (1437).

13 - Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives (1437).

14 - Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: Design, synthesis and biological evaluation (1437).

15 - Novel 2,4- thiazolidinediones: synthesis, in vitro cytotoxic activity, and mechanistic investigation (1438).

16 - Novel quinazolinone-based 2,4-thiazolidinedione-3-acetic acid derivatives as potent aldose reductase inhibitors (1439).

17 - Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: synthesis, functional evaluation and molecular modeling study (1438).

18 - Synthesis and anticancer activity of novel quinazolinone-based rhodanines (1438).

19 - Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study (1438).

20 - Synthesis and anticancer activity of novel quinazolinone‑based rhodanines (1439).

21 - Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. (1439).

22 - Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. (1439).

23 - Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells (1440).

24 - A novel scaffold to fight Pseudomonas aeruginosa pyocyanin production: early steps to novel antivirulence drugs (1441).

25 - 2-Hydroxyimino-6-aza-pyrimidine nucleosides: synthesis, DFT calculations, and antiviral evaluations (1442).

26 - 2-Hydroxyimino-6-aza-pyrimidine nucleosides: synthesis, DFT calculations, and antiviral evaluations† (1442).

27 - Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: in vitro, molecular docking, and SAR studies (1444).

28 - Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: design, synthesis and biological evaluation (1437).

المجالات البحثية

الكيمياء الطبية