/
بحث بيانات أعضاء هيئة التدريس - جامعة الزقازيق
بحث بيانات أعضاء هيئة التدريس
facebook
youtube
googleplus
twitter
zagazig
En
الموقع الشخصى
عمرو سليم احمد على ابو ليله
الكلية الصيدلة - القسم الصيدلانيات
الصيدلانيات
الدرجات العلمية
بكالوريوس فى الصيدلانيات, -جامعة الزقازيق [2000]
ماجستير فى الصيدلانيات, -جامعة الزقازيق [2005]
دكتوراه فى الصيدلانيات, -جامعة توكوشيما [2010]
الحالة الوظيفية الحالية :
معار
التدرج الوظيفى الأكاديمى
معيد : 5/10/2000
مدرس مساعد : 13/3/2005
مدرس : 26/10/2010
أستاذ مساعد : 26/1/2016
أستاذ : 23/2/2021
الأبحاث العلمية
1 -
Pharmaceutical Studies of Interactions Between Certain AntiHypertensive Drugs and Plasma Components or Their Substitutes.
2 -
Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: promise for clinical application (1434).
3 -
Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration (1434).
4 -
The co-delivery of oxaliplatin abrogates the immunogenic response to PEGylated siRNA-lipoplex (1434).
5 -
The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage (1435).
6 -
Ex-vivo/in-vitro anti-polyethylene glycol (PEG) immunoglobulin M production from murine splenic B cells stimulated by PEGylated liposome (1434).
7 -
Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances overall therapeutic efficacy of the encapsulated oxaliplatin (1435).
8 -
Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application (1434).
9 -
Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin (1433).
10 -
Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model: synergy or antagonism? (1433).
11 -
A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA (1432).
12 -
Application of Polyglycerol Coating to Plasmid DNA Lipoplex for the Evasion of the Accelerated Blood Clearance Phenomenon in Nucleic Acid Delivery (1435).
13 -
Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome (1435).
14 -
B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice (1435).
15 -
Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs (1435).
16 -
Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model (1433).
17 -
Targeting Anticancer Drugs to Tumor Vasculature Using Cationic Liposomes (1431).
18 -
Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor (1431).
19 -
Recent advances in tumor vasculature targeting using liposomal drug delivery systems (1430).
20 -
Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model (1430).
21 -
Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model (1430).
22 -
Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production (1435).
23 -
Relationship between the Concentration of Anti-polyethylene Glycol (PEG) Immunoglobulin M (IgM) and the Intensity of the Accelerated Blood Clearance (ABC) Phenomenon against PEGylated Liposomes in Mice (1436).
24 -
Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed (1437).
25 -
Intra-tumor distribution of PEGylated liposome upon repeated injection: No possession by prior dose (1437).
26 -
Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model (1437).
27 -
Downregulation of thymidylate synthase by RNAi molecules enhances the antitumor effect of pemetrexed in an orthotopic malignant mesothelioma xenograft mouse model (1437).
28 -
Improvement of intratumor microdistribution of PEG ylated liposome via tumor priming by metronomic S-1 dosing (1438).
29 -
Systemically Administered RNAi Molecule Sensitizes Malignant Pleural Mesotheliomal Cells to Pemetrexed Therapy (1437).
30 -
Ganglioside inserted into PEGylated liposome attenuates anti-PEG immunity (1438).
31 -
Liposomal Delivery Systems: Design Optimization and Current Applications (1438).
32 -
Co-administration of liposomal l-OHP and PEGylated TS shRNA-lipoplex: A novel approach to enhance anti-tumor efficacy and reduce the immunogenic response to RNAi molecules (1438).
33 -
Metronomic chemotherapy and nanocarrier platforms (1438).
34 -
Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model (1438).
35 -
Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model (1438).
36 -
Preparation and characterization of intravaginal vardenafil suppositories targeting a complementary treatment to boost in vitro fertilization process (1439).
37 -
Fast disintegrating tablet of Valsartan for the treatment of pediatric hypertension: In vitro and in vivo evaluation (1439).
38 -
Liposomal Nanomedicine (1435).
39 -
Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery (1434).
40 -
Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens (1439).
41 -
Cationic liposomes and tumor vasculature targeting: A therapeutic approach that has potential for solid tumors (1432).
42 -
Intratumoral Visualization of Oxaliplatin within a Liposomal Formulation Using X‑ray Fluorescence Spectrometry (1439).
43 -
A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes (1439).
44 -
A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research (1439).
45 -
Doxorubicin Expands in Vivo Secretion of Circulating Exosome in Mice (1439).
46 -
Design, in vitro/in vivo evaluation of meclizine HCl-loaded floating microspheres targeting pregnancy-related nausea and vomiting (1440).
47 -
Immune Response to PEGylated Nanomedicines: Impact of IgM Response (1439).
48 -
Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways (1440).
49 -
A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics (1440).
50 -
Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways. (1440).
51 -
A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes (1440).
52 -
PEGylation and anti-PEG antibodies (1439).
53 -
Anti-PEG IgM Production via a PEGylated Nanocarrier System for Nucleic Acid Delivery (1440).
54 -
A simplified method for manufacturing RNAi therapeutics for local administration (1440).
55 -
PEGylated liposomes: immunological responses (1440).
56 -
Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues (1441).
57 -
"Immunological responses to PEGylated proteins: anti-PEG antibodies" (1441).
58 -
Pegfilgrastim (PEG-G-CSF) Induces Anti-polyethylene Glycol (PEG) IgM via a T Cell-Dependent Mechanism (1442).
59 -
A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma (1441).
60 -
Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil®) in C26 Tumor-Bearing Immunocompetent Mice (1442).
61 -
Development and optimization of dual drug-loaded nanoparticles for the potent anticancer effect on renal carcinoma (1442).
62 -
Impact of Pre-Existing or Induced Anti-PEG IgM on the Pharmacokinetics of Peginterferon Alfa-2a (Pegasys) in Mice (1441).
63 -
Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice (1441).
64 -
Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon (1441).
65 -
Treatment of pulmonary arterial hypertension by vardenafil-solid dispersion lozenges as a potential alternative drug delivery system (1441).
66 -
Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes (1442).
67 -
Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice (1442).
68 -
Enhanced Cytotoxic Activity of Docetaxel-Loaded Silk Fibroin Nanoparticles against Breast Cancer Cells (1442).
69 -
Ghatti gum-base graft copolymer: a plausible platform for pH-controlled delivery of antidiabetic drugs (1442).
70 -
Synthesis of Gold Nanoparticles by Using Green Machinery: Characterization and In Vitro Toxicity (1442).
71 -
Pulmonary Targeting of Inhalable Moxifloxacin Microspheres for Effective Management of Tuberculosis (1442).
72 -
Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection (1442).
73 -
Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma (1442).
74 -
Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer (1442).
75 -
Folic acid-conjugated raloxifene-loaded graphene-based nanocarrier: Fabrication, characterization and antitumor screening (1443).
76 -
Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer (1443).
77 -
Preparation, characterization and evaluation of anti-inflammatory and anti-nociceptive effects of brucine-loaded nanoemulgel (1443).
78 -
Tamoxifen-loaded functionalized graphene nanoribbons for breast cancer therapy (1442).
79 -
Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System (1443).
80 -
Brucine‑Loaded Ethosomal Gel: Design, Optimization, and Anti‑inflammatory Activity (1443).
81 -
Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine (1443).
82 -
Design, synthesis and cytotoxic evaluation of 2-amino-4- aryl-6-substituted pyridine-3,5-dicarbonitrile derivatives (1443).
83 -
I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors (1443).
84 -
Preparation, characterization and evaluation of anti-inflammatory and anti-nociceptive effects of brucine-loaded nanoemulgel (1443).
85 -
Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System (1443).
86 -
A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes (1443).
87 -
Development and Evaluation of Clove and Cinnamon Supercritical Fluid Extracts-Loaded Emulgel for Antifungal Activity in Denture Stomatitis (1443).
88 -
Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity (1443).
89 -
Pulmonary Targeting of Levofloxacin Using Microsphere-Based Dry Powder Inhalation (1443).
90 -
Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery (1443).
91 -
Enhancement of Vancomycin Potential against Pathogenic Bacterial Strains via Gold Nano-Formulations: A Nano-Antibiotic Approach (1443).
92 -
Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin (1443).
93 -
Screening of Apoptosis Pathway-Mediated Anti-Proliferative Activity of the Phytochemical Compound Furanodienone against Human Non-Small Lung Cancer A-549 Cells (1443).
94 -
Poly "-Carpolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model (1443).
95 -
Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia (1444).
96 -
Bioactive principles, anti-diabetic, and anti-ulcer activities of Ducrosia anethifolia Boiss leaves from the Hail region, Saudi Arabia (1444).
97 -
Biosynthesis of Silver Nanoparticles Using Commiphora mukul Extract: Evaluation of Anti-Arthritic Activity in Adjuvant-Induced Arthritis Rat Model (1444).
98 -
Cytotoxic and Apoptotic Effect of Rubus chingii Leaf Extract against Non-Small Cell Lung Carcinoma A549 Cells (1444).
99 -
Delafloxacin-Capped Gold Nanoparticles (DFX-AuNPs): An Effective Antibacterial Nano-Formulation of Fluoroquinolone Antibiotic (1444).
100 -
Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity (1444).
101 -
Gold Nanoparticle-Based Resuscitation of Cefoxitin against Clinical Pathogens: A Nano-Antibiotic Strategy to Overcome Resistance (1444).
102 -
Inflammation targeted nanomedicines: Patents and applications in cancer therapy (1444).
103 -
Manganese chloride (MnCl2) induced novel model of Parkinson’s disease in adult Zebrafish; Involvement of oxidative stress, neuroinflammation and apoptosis pathway (1444).
104 -
Phytosomes as a Plausible Nano-Delivery System for Enhanced Oral Bioavailability and Improved Hepatoprotective Activity of Silymarin (1443).
105 -
Spectral Analysis and Antiulcer Potential of Lactuca sativa through the Amelioration of Proinflammatory Cytokines and Apoptosis Markers (1444).
106 -
Vardenafil-Loaded BilosomalMucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation (1444).
107 -
Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity (1444).
108 -
Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens (1444).
109 -
Biofilm Lifestyle in Recurrent Urinary Tract Infections (1444).
110 -
Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins (1444).
111 -
Coleus aromaticus Ethanolic Leaves Mediate Inhibition of NF-B Signaling Pathway in Lung Adenocarcinoma A549 Cells (1444).
112 -
Development and Characterization of Pullulan-Based Orodispersible Films of Iron (1444).
113 -
Ganetespib with Methotrexate Acts Synergistically to Impede NF-κB/p65 Signaling in Human Lung Cancer A549 Cells (1444).
114 -
Nano-Conversion of Ineffective Cephalosporins into Potent One against Resistant Clinical Uro-Pathogens via Gold Nanoparticles (1444).
115 -
Tailoring of Novel Bile Salt Stabilized Vesicles for Enhanced Transdermal Delivery of Simvastatin: A New Therapeutic Approach against Inflammation (1444).
116 -
The flavonoid hesperidin methyl chalcone as a potential therapeutic agent for cancer therapy: Molecular docking, in vitro cytotoxicity, and in vivo antitumor activity (1444).
117 -
Optimization of Potential Nanoemulgels for Boosting Transdermal Glimepiride Delivery and Upgrading Its Anti-Diabetic Activity (1444).
118 -
Anticancer potentials of metformin loaded coconut oil nanoemulsion on MCF-7, HepG2 and HCT-116 cell lines (1445).
119 -
Numerical optimization of Lenalidomide immunomodulatory drug inside the supercritical carbon dioxide system using different machine learning models (1445).
120 -
Cytotoxic Potential of Clarithromycin-Loaded Pumpkin Seed Oil-Based Nanoemulsion on Human Breast, Hepatic and Colorectal Cancer Cells (1445).
121 -
Development of Carvedilol Nanoformulation-Loaded Poloxamer-Based In Situ Gel for the Management of Glaucoma (1445).
122 -
Dual targeting multiwalled carbon nanotubes for improved neratinib delivery in breast cancer (1445).
123 -
Formulation optimization, in vitro and in vivo evaluation of niosomal nanocarriers for enhanced topical delivery of cetirizine (1445).
124 -
In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives (1444).
125 -
Nano-Formulating Besifloxacin and Employing Quercetin as a Synergizer to Enhance the Potency of Besifloxacin against Pathogenic Bacterial Strains: A Nano-Synergistic Approach (1444).
126 -
Ocular Delivery of Bimatoprost-Loaded Solid Lipid Nanoparticles for Effective Management of Glaucoma (1444).
127 -
Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis (1444).
128 -
The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens (1445).
129 -
Tailoring of Bilosomal Nanogel for Augmenting the Off-Label Use of Sildenafil Citrate in Pediatric Pulmonary Hypertension (1445).
130 -
Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia (1445).
131 -
Bacteriophage resurrection: Innovative impacts in medicine, biotechnology, and environmental solutions (1446).
المجالات البحثية
rug Formulation, Cancer Therapy, Gene Therapy, PEGylation, Liposomal delivery systems
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
شراقوة | الشرقية بين ايديك
اخبار الشرقية - شراقوة | الشرقية بين ايديك
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف
